Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse models of peripheral neuropathy. We tested the...

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Chi tiết về thư mục
Những tác giả chính: Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough
Định dạng: Bài viết
Ngôn ngữ:English
Được phát hành: Frontiers Media S.A. 2018-06-01
Loạt:Frontiers in Neuroscience
Những chủ đề:
muscarinic receptors
mitochondria
antagonist
G proteins
cytoskeleton dynamics
mitochondrial trafficking
Truy cập trực tuyến:https://www.frontiersin.org/article/10.3389/fnins.2018.00402/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00402/full

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