Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

Developmental maturation of the hematopoietic system controlled by a Lin28b-let-7-Cbx2 axis

Summary: Hematopoiesis changes over life to meet the demands of maturation and aging. Here, we find that the definitive hematopoietic stem and progenitor cell (HSPC) compartment is remodeled from gestation into adulthood, a process regulated by the heterochronic Lin28b/let-7 axis. Native fetal and n...

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Bibliographic Details
Main Authors: Dahai Wang, Mayuri Tanaka-Yano, Eleanor Meader, Melissa A. Kinney, Vivian Morris, Edroaldo Lummertz da Rocha, Nan Liu, Tianxin Liu, Qian Zhu, Stuart H. Orkin, Trista E. North, George Q. Daley, R. Grant Rowe
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:Cell Reports
Subjects:
CP: Developmental Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472200331X

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http://www.sciencedirect.com/science/article/pii/S221112472200331X

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