Ceftazidime-assisted synthesis of ultrasmall chitosan nanoparticles for biofilm penetration and eradication of Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa (P. aeruginosa) infections present a grave threat to immunocompromised individuals, particularly those with cystic fibrosis due to the development of bacterial biofilms. In this study, we engineered self-assembling chitosan-ceftazidime nanoparticles (CSCE) capable of...

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Bibliographic Details
Main Authors: Xiaoran Zheng, Min Gao, Liangquan Wu, Xin Lu, Qiuqi Lin, Hai Zhong, Yingfei Lu, Yunlei Zhang, Xiuwei Zhang
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-40653-0