Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window

Glutamate-releasing BEST1 channel is a new target for neuroprotection against ischemic stroke with wide time window

Many efforts have been made to understand excitotoxicity and develop neuroprotectants for the therapy of ischemic stroke. The narrow treatment time window is still to be solved. Given that the ischemic core expanded over days, treatment with an extended time window is anticipated. Bestrophin 1 (BEST...

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Bibliographic Details
Main Authors: Shuai Xiong, Hui Xiao, Meng Sun, Yunjie Liu, Ling Gao, Ke Xu, Haiying Liang, Nan Jiang, Yuhui Lin, Lei Chang, Haiyin Wu, Dongya Zhu, Chunxia Luo
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Acta Pharmaceutica Sinica B
Subjects:
BEST1
Ischemic stroke
Glutamate release
Delayed excitotoxicity
Infarct expansion
Neurological functions
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383523001570

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http://www.sciencedirect.com/science/article/pii/S2211383523001570

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