Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Stimulating collateral arteriogenesis is an attractive therapeutic target for peripheral artery disease (PAD). However, the potency of arteriogenesis-stimulation in animal models has not been matched with efficacy in clinical trials. This may be because the presence of enlarged collaterals is not su...

Full description

Bibliographic Details
Main Authors: Alexander Silva, Christopher J. Hatch, Megan T. Chu, Trevor R. Cardinal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
arteriogenesis
vasodilation
vascular tone
sympathetic
adrenergic
ischemia
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.805810/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.805810/full

Similar Items