Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Collateral Arteriogenesis Involves a Sympathetic Denervation That Is Associated With Abnormal α-Adrenergic Signaling and a Transient Loss of Vascular Tone

Stimulating collateral arteriogenesis is an attractive therapeutic target for peripheral artery disease (PAD). However, the potency of arteriogenesis-stimulation in animal models has not been matched with efficacy in clinical trials. This may be because the presence of enlarged collaterals is not su...

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Bibliographic Details
Main Authors: Alexander Silva, Christopher J. Hatch, Megan T. Chu, Trevor R. Cardinal
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
arteriogenesis
vasodilation
vascular tone
sympathetic
adrenergic
ischemia
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.805810/full

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