Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

Global DNA hypomethylation of colorectal tumours detected in tissue and liquid biopsies may be related to decreased methyl-donor content

Abstract Background Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecules’ (folic acid and S-adenosylmethionine) availability can contribute...

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Main Authors: Krisztina A. Szigeti, Alexandra Kalmár, Orsolya Galamb, Gábor Valcz, Barbara K. Barták, Zsófia B. Nagy, Sára Zsigrai, Ildikó Felletár, Árpád V. Patai, Tamás Micsik, Márton Papp, Eszter Márkus, Zsolt Tulassay, Peter Igaz, István Takács, Béla Molnár
Format: Article
Language:English
Published: BMC 2022-06-01
Series:BMC Cancer
Subjects:
Colorectal cancer
Epigenetics
DNA methylation
Liquid biopsy
Folic acid
S-adenosylmethionine
Online Access:https://doi.org/10.1186/s12885-022-09659-1

Internet

https://doi.org/10.1186/s12885-022-09659-1

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