Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop

Bile Acid Conjugation on Solid Nanoparticles Enhances ASBT‐Mediated Endocytosis and Chylomicron Pathway but Weakens the Transcytosis by Inducing Transport Flow in a Cellular Negative Feedback Loop

Abstract Bile acid‐modified nanoparticles provide a convenient strategy to improve oral bioavailability of poorly permeable drugs by exploiting specific interactions with bile acid transporters. However, the underlying mechanisms are unknown, especially considering the different absorption sites of...

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Bibliographic Details
Main Authors: Feiyang Deng, Kyoung Sub Kim, Jiyoung Moon, You Han Bae
Format: Article
Language:English
Published: Wiley 2022-07-01
Series:Advanced Science
Subjects:
apical sodium dependent bile acid transporter (ASBT)
bile acid‐modified nanoparticles
chylomicron pathway
transcytosis
transport feedback
Online Access:https://doi.org/10.1002/advs.202201414

Internet

https://doi.org/10.1002/advs.202201414

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