Effect of Fragment 1 on the Binding of Epigallocatechin Gallate to the PD-L1 Dimer Explored by Molecular Dynamics

Effect of Fragment 1 on the Binding of Epigallocatechin Gallate to the PD-L1 Dimer Explored by Molecular Dynamics

Blocking the interaction between programmed cell death-1 (PD-1) and programmed cell death-ligand 1 (PD-L1) by directly targeting the PD-L1 dimer has emerged as a hot topic in the field of cancer immunotherapy. Epigallocatechin gallate (EGCG), a natural product, has been demonstrated binding to the P...

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Bibliographic Details
Main Authors: Yan Guo, Yilin Guo, Zichao Guo, Boping Liu, Jianguo Xu
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Molecules
Subjects:
PD-1/PD-L1 pathway
epigallocatechin gallate
fragment 1
cancer immunotherapy
molecular dynamics simulation
Online Access:https://www.mdpi.com/1420-3049/28/23/7881

Internet

https://www.mdpi.com/1420-3049/28/23/7881

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