Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups

Hexokinase 2 Inhibition and Biological Effects of BNBZ and Its Derivatives: The Influence of the Number and Arrangement of Hydroxyl Groups

Hexokinase 2 (HK2), an enzyme of the sugar kinase family, plays a dual role in glucose metabolism and mediating cancer cell apoptosis, making it an attractive target for cancer therapy. While positive HK2 expression usually promotes cancer cells survival, silencing or inhibiting this enzyme has been...

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Bibliographic Details
Main Authors: Karolina Juszczak, Anna Kubicka, Radosław Kitel, Grzegorz Dzido, Magdalena Łabieniec-Watała, Serafin Zawadzki, Agnieszka Marczak, Krzysztof Walczak, Karolina Matczak, Mateusz D. Tomczyk
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
hexokinase 2
Warburg effect
benitrobenzerazide
enzyme inhibition
aggregation
Online Access:https://www.mdpi.com/1422-0067/23/5/2616

Internet

https://www.mdpi.com/1422-0067/23/5/2616

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