Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

Summary: T cell responses precede antibody and may provide early control of infection. We analyzed the clonal basis of this rapid response following SARS-COV-2 infection. We applied T cell receptor (TCR) sequencing to define the trajectories of individual T cell clones immediately. In SARS-COV-2 PCR...

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Bibliographic Details
Main Authors: Martina Milighetti, Yanchun Peng, Cedric Tan, Michal Mark, Gayathri Nageswaran, Suzanne Byrne, Tahel Ronel, Tom Peacock, Andreas Mayer, Aneesh Chandran, Joshua Rosenheim, Matthew Whelan, Xuan Yao, Guihai Liu, Suet Ling Felce, Tao Dong, Alexander J. Mentzer, Julian C. Knight, Francois Balloux, Erez Greenstein, Shlomit Reich-Zeliger, Corinna Pade, Joseph M. Gibbons, Amanda Semper, Tim Brooks, Ashley Otter, Daniel M. Altmann, Rosemary J. Boyton, Mala K. Maini, Aine McKnight, Charlotte Manisty, Thomas A. Treibel, James C. Moon, Mahdad Noursadeghi, Benny Chain
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Biological sciences
Immunology
Immunity
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010143

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http://www.sciencedirect.com/science/article/pii/S2589004223010143

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