Reestablishment of spermatogenesis after more than 20 years of cryopreservation of rat spermatogonial stem cells reveals an important impact in differentiation capacity.

Treatment of cancer in children is increasingly successful but leaves many prepubertal boys suffering from infertility or subfertility later in life. A current strategy to preserve fertility in these boys is to cryopreserve a testicular biopsy prior to treatment with the expectation of future techno...

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Bibliographic Details
Main Authors: Eoin C Whelan, Fan Yang, Mary R Avarbock, Megan C Sullivan, Daniel P Beiting, Ralph L Brinster
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-05-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3001618