Targeting Stress Sensor Kinases in Hepatocellular Carcinoma-Infiltrating Human NK Cells as a Novel Immunotherapeutic Strategy for Liver Cancer

Targeting Stress Sensor Kinases in Hepatocellular Carcinoma-Infiltrating Human NK Cells as a Novel Immunotherapeutic Strategy for Liver Cancer

Natural killer (NK) cells may become functionally exhausted entering hepatocellular carcinoma (HCC), and this has been associated with tumor progression and poor clinical outcome. Hypoxia, low nutrients, immunosuppressive cells, and soluble mediators characterize the intratumor microenvironment res...

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Bibliographic Details
Main Authors: Alessandra Zecca, Valeria Barili, Andrea Olivani, Elisabetta Biasini, Carolina Boni, Paola Fisicaro, Ilaria Montali, Camilla Tiezzi, Raffaele Dalla Valle, Carlo Ferrari, Elisabetta Cariani, Gabriele Missale
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
immunometabolism
NK-cell
immunotherapy
hepatocellular carcinoma
oncoimmunology
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.875072/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.875072/full

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