Targeting Stress Sensor Kinases in Hepatocellular Carcinoma-Infiltrating Human NK Cells as a Novel Immunotherapeutic Strategy for Liver Cancer

Targeting Stress Sensor Kinases in Hepatocellular Carcinoma-Infiltrating Human NK Cells as a Novel Immunotherapeutic Strategy for Liver Cancer

Natural killer (NK) cells may become functionally exhausted entering hepatocellular carcinoma (HCC), and this has been associated with tumor progression and poor clinical outcome. Hypoxia, low nutrients, immunosuppressive cells, and soluble mediators characterize the intratumor microenvironment res...

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Bibliografiska uppgifter
Huvudupphovsmän: Alessandra Zecca, Valeria Barili, Andrea Olivani, Elisabetta Biasini, Carolina Boni, Paola Fisicaro, Ilaria Montali, Camilla Tiezzi, Raffaele Dalla Valle, Carlo Ferrari, Elisabetta Cariani, Gabriele Missale
Materialtyp: Artikel
Språk:English
Publicerad: Frontiers Media S.A. 2022-05-01
Serie:Frontiers in Immunology
Ämnen:
immunometabolism
NK-cell
immunotherapy
hepatocellular carcinoma
oncoimmunology
Länkar:https://www.frontiersin.org/articles/10.3389/fimmu.2022.875072/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.875072/full

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