Queuine ameliorates impaired mitochondrial function caused by mt-tRNAAsn variants

Queuine ameliorates impaired mitochondrial function caused by mt-tRNAAsn variants

Abstract Background Mitochondrial tRNA (mt-tRNA) variants have been found to cause disease. Post-transcriptional queuosine (Q) modifications of mt-tRNA can promote efficient mitochondrial mRNA translation. Q modifications of mt-tRNAAsn have recently been identified. Here, the therapeutic effectivene...

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Bibliographic Details
Main Authors: Yan Lin, Jiayin Wang, Xingyu Zhuang, Ying Zhao, Wei Wang, Dongdong Wang, Yuying Zhao, Chuanzhu Yan, Kunqian Ji
Format: Article
Language:English
Published: BMC 2024-08-01
Series:Journal of Translational Medicine
Subjects:
Mitochondrial disease
mt-tRNAAsn
m.5708C > T
Queuine
Therapy
Online Access:https://doi.org/10.1186/s12967-024-05574-0

Internet

https://doi.org/10.1186/s12967-024-05574-0

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