Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers

Synthesis and Antiproliferative Activity of Steroidal Diaryl Ethers

Novel 13α-estrone derivatives have been synthesized via direct arylation of the phenolic hydroxy function. Chan–Lam couplings of arylboronic acids with 13α-estrone as a nucleophilic partner were carried out under copper catalysis. The antiproliferative activities of the newly synthesized diaryl ethe...

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Bibliographic Details
Main Authors: Édua Kovács, Hazhmat Ali, Renáta Minorics, Péter Traj, Vivien Resch, Gábor Paragi, Bella Bruszel, István Zupkó, Erzsébet Mernyák
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
Chan–Lam reaction
diaryl ether
13α-estrone
antiproliferative effect
tubulin polymerization
molecular dynamics
Online Access:https://www.mdpi.com/1420-3049/28/3/1196

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https://www.mdpi.com/1420-3049/28/3/1196

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