Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Increased VLCFA-lipids and ELOVL4 underlie neurodegeneration in frontotemporal dementia

Abstract Rare, yet biologically critical, lipids that contain very long chain fatty acids (VLCFA-lipids) are synthesized in the brain by the enzyme ELOVL4. High levels of VLCFA-lipids are toxic to cells and excess VLCFA-lipids are actively removed by ABCD1 in an ATP-dependent manner. Virtually nothi...

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Bibliographic Details
Main Authors: Ying He, Katherine Phan, Surabhi Bhatia, Russell Pickford, YuHong Fu, Yue Yang, John R. Hodges, Olivier Piguet, Glenda M. Halliday, Woojin Scott Kim
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-00870-x

Internet

https://doi.org/10.1038/s41598-021-00870-x

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