Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

Molecular elements in FGF19 and FGF21 defining KLB/FGFR activity and specificity

Objective: To signal, FGF19 and FGF21 require co-receptor βKlotho (KLB) to act in concert with FGF receptors, and yet there is appreciable variance in the C-terminal sequences of these two novel metabolic hormones where binding is believed to be primary. We seek to determine the functional consequen...

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Bibliographic Details
Main Authors: Archita Agrawal, Sebastian Parlee, Diego Perez-Tilve, Pengyun Li, Jia Pan, Piotr A. Mroz, Ann Maria Kruse Hansen, Birgitte Andersen, Brian Finan, Alexei Kharitonenkov, Richard D. DiMarchi
Format: Article
Language:English
Published: Elsevier 2018-07-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S221287781830423X

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http://www.sciencedirect.com/science/article/pii/S221287781830423X

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