Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade

Reversing immunosuppression in the tumor microenvironment of fibrolamellar carcinoma via PD-1 and IL-10 blockade

Abstract Fibrolamellar carcinoma (FLC) is a rare liver tumor driven by the DNAJ-PKAc fusion protein that affects healthy young patients. Little is known about the immune response to FLC, limiting rational design of immunotherapy. Multiplex immunohistochemistry and gene expression profiling were perf...

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Bibliographic Details
Main Authors: S. K. Daniel, K. M. Sullivan, L. K. Dickerson, R. J. E. van den Bijgaart, A. F. Utria, K. P. Labadie, H. L. Kenerson, X. Jiang, K. S. Smythe, J. S. Campbell, R. H. Pierce, T. S. Kim, K. J. Riehle, R. S. Yeung, J. A. Carter, K. C. Barry, V. G. Pillarisetty
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-55593-6

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https://doi.org/10.1038/s41598-024-55593-6

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