The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function
Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-05-01
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| Series: | Toxins |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2072-6651/10/6/218 |
| _version_ | 1828151984869343232 |
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| author | Lucie Hénaut Aurélien Mary Jean-Marc Chillon Saïd Kamel Ziad A. Massy |
| author_facet | Lucie Hénaut Aurélien Mary Jean-Marc Chillon Saïd Kamel Ziad A. Massy |
| author_sort | Lucie Hénaut |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs’ physiological functions. Chronic, low-grade inflammation and oxidative stress—hallmarks of CKD—are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling. |
| first_indexed | 2024-04-11T22:05:23Z |
| format | Article |
| id | doaj.art-a3eeb85ad28543b6940cb6911f4871f7 |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-04-11T22:05:23Z |
| publishDate | 2018-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-a3eeb85ad28543b6940cb6911f4871f72022-12-22T04:00:44ZengMDPI AGToxins2072-66512018-05-0110621810.3390/toxins10060218toxins10060218The Impact of Uremic Toxins on Vascular Smooth Muscle Cell FunctionLucie Hénaut0Aurélien Mary1Jean-Marc Chillon2Saïd Kamel3Ziad A. Massy4MP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceMP3CV, EA7517, CURS, Jules Verne University of Picardie, 80054 Amiens, FranceAmbroise Paré University Hospital, Division of Nephrology, APHP, 92100 Boulogne-Billancourt/Paris, FranceChronic kidney disease (CKD) is associated with profound vascular remodeling, which accelerates the progression of cardiovascular disease. This remodeling is characterized by intimal hyperplasia, accelerated atherosclerosis, excessive vascular calcification, and vascular stiffness. Vascular smooth muscle cell (VSMC) dysfunction has a key role in the remodeling process. Under uremic conditions, VSMCs can switch from a contractile phenotype to a synthetic phenotype, and undergo abnormal proliferation, migration, senescence, apoptosis, and calcification. A growing body of data from experiments in vitro and animal models suggests that uremic toxins (such as inorganic phosphate, indoxyl sulfate and advanced-glycation end products) may directly impact the VSMCs’ physiological functions. Chronic, low-grade inflammation and oxidative stress—hallmarks of CKD—are also strong inducers of VSMC dysfunction. Here, we review current knowledge about the impact of uremic toxins on VSMC function in CKD, and the consequences for pathological vascular remodeling.http://www.mdpi.com/2072-6651/10/6/218chronic kidney diseaseuremic toxinsvascular smooth muscle cells |
| spellingShingle | Lucie Hénaut Aurélien Mary Jean-Marc Chillon Saïd Kamel Ziad A. Massy The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function Toxins chronic kidney disease uremic toxins vascular smooth muscle cells |
| title | The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |
| title_full | The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |
| title_fullStr | The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |
| title_full_unstemmed | The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |
| title_short | The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function |
| title_sort | impact of uremic toxins on vascular smooth muscle cell function |
| topic | chronic kidney disease uremic toxins vascular smooth muscle cells |
| url | http://www.mdpi.com/2072-6651/10/6/218 |
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