Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes

Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in isolated mouse ventricular myocytes

BackgroundThe Bruton tyrosine kinase (BTK) inhibitor Ibrutinib is associated with a higher incidence of cardiotoxic side effects including heart failure (HF).ObjectivesIbrutinib is capable of inhibiting PI3K/Akt signaling in neonatal rat ventricular cardiomyocytes when stimulated with insulin-like g...

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Bibliographic Details
Main Authors: Daniel Tarnowski, Anna-Lena Feder, Maximilian Trum, Klaus-Georg Kreitmeier, Laura Stengel, Lars S. Maier, Can Martin Sag
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Ibrutinib
IGF-1
EC-coupling
heart failure
SR Ca handling
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1190099/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2023.1190099/full

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