The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin

The Distinct Roles of LKB1 and AMPK in p53-Dependent Apoptosis Induced by Cisplatin

Liver kinase B1 (LKB1) is a serine/threonine protein kinase that acts as a key tumor suppressor protein by activating its downstream kinases, such as AMP-activated protein kinase (AMPK). However, the regulatory actions of LKB1 and AMPK on DNA damage response (DDR) remain to be explored. In this stud...

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Bibliographic Details
Main Authors: Tatsuya Shimada, Yohsuke Yabuki, Takuya Noguchi, Mei Tsuchida, Ryuto Komatsu, Shuhei Hamano, Mayuka Yamada, Yusuke Ezaki, Yusuke Hirata, Atsushi Matsuzawa
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
LKB1
AMPKα
apoptosis
cisplatin
DNA damage
DNA damage response
Online Access:https://www.mdpi.com/1422-0067/23/17/10064

Internet

https://www.mdpi.com/1422-0067/23/17/10064

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