NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer

NAT10-mediated ac4C tRNA modification promotes EGFR mRNA translation and gefitinib resistance in cancer

Summary: Aberrant RNA modifications are frequently associated with cancers, while the underlying mechanisms and clinical significance remain poorly understood. Here, we find that the ac4C RNA acetyltransferase NAT10 is significantly upregulated in esophageal cancers (ESCAs) and associated with poor...

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Bibliographic Details
Main Authors: Wei Wei, Shuishen Zhang, Hui Han, Xiaochen Wang, Siyi Zheng, Zhaoyu Wang, Chunlong Yang, Lu Wang, Jieyi Ma, Siyao Guo, Juan Wang, Lianlian Liu, Junho Choe, Shuibin Lin
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723008215

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http://www.sciencedirect.com/science/article/pii/S2211124723008215

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