One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage

One-carbon pathway metabolites are altered in the plasma of subjects with Down syndrome: Relation to chromosomal dosage

IntroductionDown syndrome (DS) is the most common chromosomal disorder and it is caused by trisomy of chromosome 21 (Hsa21). Subjects with DS show a large heterogeneity of phenotypes and the most constant clinical features present are typical facies and intellectual disability (ID). Several studies...

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Bibliographic Details
Main Authors: Beatrice Vione, Giuseppe Ramacieri, Giacomo Zavaroni, Angela Piano, Giorgia La Rocca, Maria Caracausi, Lorenza Vitale, Allison Piovesan, Caterina Gori, Gian Luca Pirazzoli, Pierluigi Strippoli, Guido Cocchi, Luigi Corvaglia, Chiara Locatelli, Maria Chiara Pelleri, Francesca Antonaros
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Medicine
Subjects:
trisomy 21
Down syndrome
one-carbon pathway
folates
chromosomal dosage
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.1006891/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2022.1006891/full

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