Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

Developing therapeutically more efficient Neurturin variants for treatment of Parkinson's disease

In Parkinson's disease midbrain dopaminergic neurons degenerate and die. Oral medications and deep brain stimulation can relieve the initial symptoms, but the disease continues to progress. Growth factors that might support the survival, enhance the activity, or even regenerate degenerating dop...

Full description

Bibliographic Details
Main Authors: Pia Runeberg-Roos, Elisa Piccinini, Anna-Maija Penttinen, Kert Mätlik, Hanna Heikkinen, Satu Kuure, Maxim M. Bespalov, Johan Peränen, Enrique Garea-Rodríguez, Eberhard Fuchs, Mikko Airavaara, Nisse Kalkkinen, Richard Penn, Mart Saarma
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Neurobiology of Disease
Subjects:
NRTN
Neurturin
GDNF
GFRα1
GFRα2
RET
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611630167X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611630167X

Similar Items