Design, synthesis, docking studies and antibiotic evaluation (in vitro) of some novel (E)-4-(3-(diphenylamino)phenyl)-1-(4-methoxyphenyl)-2-methylbut-3-en-1-one and their analogues

Design, synthesis, docking studies and antibiotic evaluation (in vitro) of some novel (E)-4-(3-(diphenylamino)phenyl)-1-(4-methoxyphenyl)-2-methylbut-3-en-1-one and their analogues

Abstract Background Antibiotic resistance has risen as a result of a variety of conditions, prompting researchers to look for new compounds that can combat multidrug-resistant organisms. Over the last two decades, chalcones have been proved to be attractive moieties in drug discovery. Various substi...

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Bibliographic Details
Main Authors: AbdulRazaq Tukur, James Dama Habila, Rachael Gbekele-Oluwa Ayo, Ogunkemi Risikat Agbeke Iyun
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:Bulletin of the National Research Centre
Subjects:
Chalcones
Triphenylamine
Claisen–Schmidt condensation
Antimicrobial activity
Molecular docking
Binding affinity
Online Access:https://doi.org/10.1186/s42269-022-00745-9

Internet

https://doi.org/10.1186/s42269-022-00745-9

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