Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

Mice with altered serotonin 2C receptor RNA editing display characteristics of Prader–Willi syndrome

RNA transcripts encoding the 2C-subtype of serotonin (5HT2C) receptor undergo up to five adenosine-to-inosine editing events to encode twenty-four protein isoforms. To examine the effects of altered 5HT2C editing in vivo, we generated mutant mice solely expressing the fully-edited (VGV) isoform of t...

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Bibliographic Details
Main Authors: Michael V. Morabito, Atheir I. Abbas, Jennifer L. Hood, Robert A. Kesterson, Michelle M. Jacobs, David S. Kump, David L. Hachey, Bryan L. Roth, Ronald B. Emeson
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Neurobiology of Disease
Subjects:
RNA Editing
Serotonin receptor
Prader–Willi syndrome
Feeding behavior
Metabolism
Hyperphagia
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110001014

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http://www.sciencedirect.com/science/article/pii/S0969996110001014

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