EPO promotes bone repair through enhanced cartilaginous callus formation and angiogenesis.

EPO promotes bone repair through enhanced cartilaginous callus formation and angiogenesis.

Erythropoietin (EPO)/erythropoietin receptor (EPOR) signaling is involved in the development and regeneration of several non-hematopoietic tissues including the skeleton. EPO is identified as a downstream target of the hypoxia inducible factor-α (HIF-α) pathway. It is shown that EPO exerts a positiv...

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Bibliographic Details
Main Authors: Lin Wan, Fengjie Zhang, Qiling He, Wing Pui Tsang, Li Lu, Qingnan Li, Zhihong Wu, Guixing Qiu, Guangqian Zhou, Chao Wan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4087003?pdf=render

Internet

http://europepmc.org/articles/PMC4087003?pdf=render

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