Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord

Truncated wild-type SOD1 and FALS-linked mutant SOD1 cause neural cell death in the chick embryo spinal cord

Approximately 10% of amyotrophic lateral sclerosis (ALS) cases are familial (FALS), and ∼25% of FALS cases are caused by mutations in superoxide dismutase-1 (SOD1). Mutant (MT) SOD1 kills motor neurons because of the mutant protein's toxicity; however, the basis for toxicity is unknown. We elec...

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Bibliographic Details
Main Authors: Ghanashyam D. Ghadge, Lijun Wang, Kamal Sharma, Anna Liza Monti, Vytas Bindokas, Fred J. Stevens, Raymond P. Roos
Format: Article
Language:English
Published: Elsevier 2006-01-01
Series:Neurobiology of Disease
Subjects:
Familial amyotrophic lateral sclerosis
Superoxide dismutase-1
Aggregation
Apoptosis
Protein misfolding
Chick embryo spinal cord
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996105002007

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http://www.sciencedirect.com/science/article/pii/S0969996105002007

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