Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)

Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)

Ubiquitin-specific protease7 (USP7) regulates the stability of the p53 tumor suppressor protein and several other proteins critical for tumor cell survival. Aberrant expression of USP7 facilitates human malignancies by altering the activity of proto-oncogenes/proteins, and tumor suppressor genes. Th...

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Bibliographic Details
Main Authors: Seema Zadi, Sumaira Javaid, Atia-tul-Wahab, Humaira Zafar, Muhammad Awais, Innokentiy Maslennikov, M. Iqbal Choudhary
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Drug repurposing
Deubiquitinase
USP7
Anti-cancer agents
STD-NMR
Gene expression analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024023764

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http://www.sciencedirect.com/science/article/pii/S2405844024023764

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