Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis

Mesenchymal stem cell-based Smad7 gene therapy for experimental liver cirrhosis

Abstract Background Bone mesenchymal stem cells (MSCs) can promote liver regeneration and inhibit inflammation and hepatic fibrosis. MSCs also can serve as a vehicle for gene therapy. Smad7 is an essential negative regulatory gene in the TGF-β1/Smad signalling pathway. Activation of TGF-β1/Smad sign...

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Bibliographic Details
Main Authors: Dong-Na Su, Shi-Pin Wu, Shang-Zhong Xu
Format: Article
Language:English
Published: BMC 2020-09-01
Series:Stem Cell Research & Therapy
Subjects:
Mesenchymal stem cells
Smad7
Liver cirrhosis
Fibrosis
TGF-β
Gene therapy
Online Access:http://link.springer.com/article/10.1186/s13287-020-01911-4

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http://link.springer.com/article/10.1186/s13287-020-01911-4

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