Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer

Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancer

Abstract Background Triple-negative breast cancer (TBNC) is an aggressive breast cancer subtype with a poor prognosis. Shugoshin-1 (SGO1) protects chromatids from early separation. Previous studies from our group have demonstrated that transient SGO1 downregulation suppresses early stages of metasta...

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Bibliographic Details
Main Authors: Shirley Jusino, Yainyrette Rivera-Rivera, Camille Chardón-Colón, Patricia C. Rodríguez-Rodríguez, Janeishly Román-González, Valeria S. Juliá-Hernández, Angel Isidro, Qianxing Mo, Harold I. Saavedra
Format: Article
Language:English
Published: BMC 2023-04-01
Series:Cell Division
Subjects:
SGO1
Tumor growth
Metastasis
Epithelial-to-mesenchymal transition
Triple-negative breast cancer
Mitosis
Online Access:https://doi.org/10.1186/s13008-023-00088-5

Internet

https://doi.org/10.1186/s13008-023-00088-5

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