Carrier-free delivery of thymopentin-regulated injectable nanogels via an enhanced cancer immunity cycle against melanoma metastasis

Carrier-free delivery of thymopentin-regulated injectable nanogels via an enhanced cancer immunity cycle against melanoma metastasis

Thymopentin (TP5), a clinically used immunomodulatory pentapeptide, can efficiently promote thymocyte differentiation and influence mature T-cell function, thus playing an essential role in the cancer immunotherapy. However, the excellent water solubility and high IC50 of TP5 result in an uncontroll...

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Bibliographic Details
Main Authors: Ning Ding, Kai He, Hailong Tian, Lei Li, Qiong Li, Shuaijun Lu, Ke Ding, Jiaqi Liu, Edouard C. Nice, Wei Zhang, Canhua Huang, Yong Tang, Zhisen Shen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Materials Today Bio
Subjects:
Thymopentin
Nanogel
Cancer immunity cycle
Immunogenic cell death
Chemo-immunotherapy
Melanoma metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006423001059

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http://www.sciencedirect.com/science/article/pii/S2590006423001059

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