Engineered extracellular vesicles for concurrent Anti-PDL1 immunotherapy and chemotherapy

Immune checkpoint inhibitors (ICI) targeting PD-1/PD-L1 have been approved for the treatment of a variety of cancers. However, the efficacy of antibody-based ICIs could be further improved by mitigating anti-drug antibodies, proteolytic cleavage, and on-target off-tumor toxicity. One strategy for ac...

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Bibliographic Details
Main Authors: Yundi Chen, Lixue Wang, Mingfeng Zheng, Chuandong Zhu, Guosheng Wang, Yiqiu Xia, Ethan J. Blumenthal, Wenjun Mao, Yuan Wan
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-03-01
Series:Bioactive Materials
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X21003455