“Rogue” neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury – studies in human, macaque and rat LPS-inflammation models

“Rogue” neutrophil-subset [DEspR+CD11b+/CD66b+] immunotype is an actionable therapeutic target for neutrophilic inflammation-mediated tissue injury – studies in human, macaque and rat LPS-inflammation models

Background and objectiveThe correlation (Rs > 0.7) of neutrophils expressing the dual endothelin1/signal peptide receptor (DEspR+CD11b+/CD66b+) with severity of hypoxemia (SF-ratio) and multi-organ failure (SOFA-score) in patients with acute respiratory distress syndrome (ARDS) suggest the hy...

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Bibliographic Details
Main Authors: Saskia Carstensen, Meike Müller, Glaiza L. A. Tan, Khristine Amber Pasion, Jens M. Hohlfeld, Victoria L. M. Herrera, Nelson Ruiz-Opazo
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
neutrophil subset
DEspR
LPS-acute inflammation tissue injury models
acute lung injury
LPS-brain encephalopathy
segmental LPS challenge
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008390/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.1008390/full

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