Hnf1b renal expression directed by a distal enhancer responsive to Pax8

Abstract Xenopus provides a simple and efficient model system to study nephrogenesis and explore the mechanisms causing renal developmental defects in human. Hnf1b (hepatocyte nuclear factor 1 homeobox b), a gene whose mutations are the most commonly identified genetic cause of developmental kidney...

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Bibliographic Details
Main Authors: L. Goea, I. Buisson, V. Bello, A. Eschstruth, M. Paces-Fessy, R. Le Bouffant, A. Chesneau, S. Cereghini, J. F. Riou, M. Umbhauer
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-21171-x