The alleviative effects of metformin for lipopolysaccharide-induced acute lung injury rat model and its underlying mechanism

For patients who have sepsis, acute lung injury (ALI) causes most of death. Metformin (Met) is an anti-hyperglycemic agent and it has extensive pharmacological properties. This study aimed to analyze the influence of Met on lipopolysaccharide (LPS) -induced ALI. Met (1, 2, and 4 mg/kg) were injected...

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Bibliographic Details
Main Authors: Xiangcheng Zhang, Futai Shang, Liangliang Hui, Kui Zang, Gengyun Sun
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Saudi Pharmaceutical Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S131901641730107X