Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Trem2 deficiency differentially affects phenotype and transcriptome of human APOE3 and APOE4 mice

Abstract Background Alzheimer’s Disease (AD) is a neurodegenerative disorder influenced by aging and genetic risk factors. The inheritance of APOEε4 and variants of Triggering Receptor Expressed on Myeloid cells 2 (TREM2) are major genetic risk factors for AD. Recent studies showed that APOE binds t...

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Bibliographic Details
Main Authors: Nicholas F. Fitz, Cody M. Wolfe, Brittany E. Playso, Richard J. Biedrzycki, Yi Lu, Kyong Nyon Nam, Iliya Lefterov, Radosveta Koldamova
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Molecular Neurodegeneration
Subjects:
Trem2
APOE
Transcriptomics
Microglia
Neuroinflammation
Alzheimer’s disease
Online Access:http://link.springer.com/article/10.1186/s13024-020-00394-4

Internet

http://link.springer.com/article/10.1186/s13024-020-00394-4

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