Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

Optimized AAV rh.10 Vectors That Partially Evade Neutralizing Antibodies during Hepatic Gene Transfer

Of the 12 common serotypes used for gene delivery applications, Adeno-associated virus (AAV)rh.10 serotype has shown sustained hepatic transduction and has the lowest seropositivity in humans. We have evaluated if further modifications to AAVrh.10 at its phosphodegron like regions or predicted immun...

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Bibliographic Details
Main Authors: Ruchita Selot, Sathyathithan Arumugam, Bertin Mary, Sabna Cheemadan, Giridhara R. Jayandharan
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Pharmacology
Subjects:
AAV
gene therapy
immune-escape
neutralizing antibody
T-cell
B-cell
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00441/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00441/full

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