Cocaine Regulates NLRP3 Inflammasome Activity and CRF Signaling in a Region- and Sex-Dependent Manner in Rat Brain

Cocaine, one of the most abused drugs worldwide, is capable of activating microglia in vitro and in vivo. Several neuroimmune pathways have been suggested to play roles in cocaine-mediated microglial activation. Previous work showed that cocaine activates microglia in a region-specific manner in the...

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Bibliographic Details
Main Authors: Yan Cheng, Rachael Elizabeth Dempsey, Soheil Kazemi Roodsari, Dorela D. Shuboni-Mulligan, Olivier George, Larry D. Sanford, Ming-Lei Guo
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:Biomedicines
Subjects:
Online Access:https://www.mdpi.com/2227-9059/11/7/1800