N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment

N-linked glycosylation of PD-L1/PD-1: an emerging target for cancer diagnosis and treatment

Abstract During tumorigenesis and progression, the immune checkpoint programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) play critical roles in suppressing T cell-mediated anticancer immune responses, leading to T-cell exhaustion and subsequent tumor evasion. Therefore, anti-P...

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Bibliographic Details
Main Authors: Zhiyun Duan, Runhan Shi, Bo Gao, Jiabin Cai
Format: Article
Language:English
Published: BMC 2024-07-01
Series:Journal of Translational Medicine
Subjects:
PD-L1
PD-1
N-linked glycosylation
Immune evasion
Clinical diagnosis
Immunotherapy
Online Access:https://doi.org/10.1186/s12967-024-05502-2

Internet

https://doi.org/10.1186/s12967-024-05502-2

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