Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway

Benzylidene Barbituric Acid Derivatives Shown Anticonvulsant Activity on Pentylenetetrazole-Induced Seizures in Mice: Involvement of Nitric Oxide Pathway

ABSTRACT Background: Barbituric acid derivatives have long been used as central nervous system (CNS) suppressants, such as sedatives, hypnotics and anticonvulsants. In addition, previous studies have implicated the involvement of nitric oxide (NO) in the anticonvulsive effects of barbiturates in CN...

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Bibliographic Details
Main Authors: Shabnam Mahernia, Niusha Sharifi, Malihe Hassanzadeh, Nastaran Rahimi, Nastaran Pourshadi, Arash Amanlou, Ahmad Reza Dehpour, Massoud Amanlou
Format: Article
Language:English
Published: Tabriz University of Medical Sciences 2018-12-01
Series:Pharmaceutical Sciences
Subjects:
Barbituric acid
Nitric oxide
Nitric oxide synthase inhibitors
Pentylenetetrazole
Seizure
Mice
Online Access:https://ps.tbzmed.ac.ir/PDF/PHARM_3497_20180619145232

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