Suppressing circ_0008494 inhibits HSCs activation by regulating the miR-185-3p/Col1a1 axis

Suppressing circ_0008494 inhibits HSCs activation by regulating the miR-185-3p/Col1a1 axis

Background: Hepatic fibrosis (HF) is characterized by activation of hepatic stellate cells (HSCs) and extensive deposition of extracellular matrix components, especially collagens. However, effective antifibrotic therapies are still lacking. Recently, circular RNAs (circRNAs) have been identified as...

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Bibliographic Details
Main Authors: Binbin Li, Jiaming Zhou, Yuanyuan Luo, Kegong Tao, Lifen Zhang, Ying Zhao, Yong Lin, Xin Zeng, Hongyu Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Pharmacology
Subjects:
circ_0008494
hepatic fibrosis
hepatic stellate cells
miR-185-3p
Col1a1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1050093/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.1050093/full

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