The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

Abstract Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1), secreted from cancer cells and hepatocytes, facilitates the progression of CRC i...

Full description

Bibliographic Details
Main Authors: Jia-Jun Li, Jin-Hong Wang, Tian Tian, Jia Liu, Yong-Qiang Zheng, Hai-Yu Mo, Hui Sheng, Yan-Xing Chen, Qi-Nian Wu, Yi Han, Kun Liao, Yi-Qian Pan, Zhao-Lei Zeng, Ze-Xian Liu, Wei Yang, Rui-Hua Xu, Huai-Qiang Ju
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42332-0

Internet

https://doi.org/10.1038/s41467-023-42332-0

Similar Items