The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

The influence of antibody engineering on Fc conformation and Fc receptor binding properties: Analysis of FcRn-binding engineered antibodies and an Fc fusion protein

Therapeutic immunoglobulin G (IgG) antibodies have comparatively long half-lives because the neonatal Fc receptor (FcRn) binds to the IgG Fc at acidic pH in the endosome and protects IgG from degradation. To further prolong the half-lives, amino acid-substituted antibodies having high affinity to Fc...

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Bibliographic Details
Main Authors: Takuo Suzuki, Noritaka Hashii, Minoru Tada, Akiko Ishii-Watabe
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
FcRn
FcγR
affinity
HDX-MS
conformation of Fc
engineered antibody
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1923366

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1923366

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