The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis

Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.

Bibliographic Details
Main Authors: Xiao Zhang, Yongxia Qiao, Qi Wu, Yan Chen, Shaowu Zou, Xiangfan Liu, Guoqing Zhu, Yinghui Zhao, Yuxin Chen, Yongchun Yu, Qiuhui Pan, Jiayi Wang, Fenyong Sun
Format: Article
Language:English
Published: Nature Portfolio 2017-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15280

Internet

https://doi.org/10.1038/ncomms15280

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