The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.
Bibliographic Details
| Main Authors: |
Xiao Zhang,
Yongxia Qiao,
Qi Wu,
Yan Chen,
Shaowu Zou,
Xiangfan Liu,
Guoqing Zhu,
Yinghui Zhao,
Yuxin Chen,
Yongchun Yu,
Qiuhui Pan,
Jiayi Wang,
Fenyong Sun |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Portfolio
2017-05-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/ncomms15280
|
|---|