The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis
Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15280 |
| _version_ | 1818857936404873216 |
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| author | Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun |
| author_facet | Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun |
| author_sort | Xiao Zhang |
| collection | DOAJ |
| description | Yap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development. |
| first_indexed | 2024-12-19T08:48:19Z |
| format | Article |
| id | doaj.art-a41aed7f74b947d7ae8619b5e9637eb2 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:48:19Z |
| publishDate | 2017-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-a41aed7f74b947d7ae8619b5e9637eb22022-12-21T20:28:48ZengNature PortfolioNature Communications2041-17232017-05-018111510.1038/ncomms15280The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesisXiao Zhang0Yongxia Qiao1Qi Wu2Yan Chen3Shaowu Zou4Xiangfan Liu5Guoqing Zhu6Yinghui Zhao7Yuxin Chen8Yongchun Yu9Qiuhui Pan10Jiayi Wang11Fenyong Sun12Department of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversitySchool of Public Health, Shanghai Jiaotong University School of MedicineDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Hepatopancreatobiliary, Shanghai Tenth People’s Hospital of Tongji UniversityFaculty of Medical Laboratory Science, Shanghai Jiaotong University School of MedicineDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityShanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese MedicineDepartment of Central Laboratory, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Clinical Laboratory Medicine, Shanghai Tenth People’s Hospital of Tongji UniversityYap is a transcriptional factor involved in tumorigenesis. Here the authors show that a previously unknown post-translational modification of Yap, O-GlcNAcylation, increases its transcriptional activity and is required for high glucose-induced liver cancer development.https://doi.org/10.1038/ncomms15280 |
| spellingShingle | Xiao Zhang Yongxia Qiao Qi Wu Yan Chen Shaowu Zou Xiangfan Liu Guoqing Zhu Yinghui Zhao Yuxin Chen Yongchun Yu Qiuhui Pan Jiayi Wang Fenyong Sun The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis Nature Communications |
| title | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis |
| title_full | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis |
| title_fullStr | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis |
| title_full_unstemmed | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis |
| title_short | The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis |
| title_sort | essential role of yap o glcnacylation in high glucose stimulated liver tumorigenesis |
| url | https://doi.org/10.1038/ncomms15280 |
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