The Polyphosphate Kinase of <named-content content-type="genus-species">Escherichia coli</named-content> Is Required for Full Production of the Genotoxin Colibactin

The Polyphosphate Kinase of <named-content content-type="genus-species">Escherichia coli</named-content> Is Required for Full Production of the Genotoxin Colibactin

ABSTRACT Colibactin induces DNA damage in mammalian cells and has been linked to the virulence of Escherichia coli and the promotion of colorectal cancer (CRC). By looking for mutants attenuated in the promoter activity of clbB encoding one of the key enzymes for the production of colibactin, we fou...

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Bibliographic Details
Main Authors: Min Tang-Fichaux, Camille V. Chagneau, Nadège Bossuet-Greif, Jean-Philippe Nougayrède, Éric Oswald, Priscilla Branchu
Format: Article
Language:English
Published: American Society for Microbiology 2020-12-01
Series:mSphere
Subjects:
pks
genotoxicity
PPK
mesalamine
colibactin
Online Access:https://journals.asm.org/doi/10.1128/mSphere.01195-20

Internet

https://journals.asm.org/doi/10.1128/mSphere.01195-20

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