Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors

Synthesis, Cytotoxic Evaluation, and Structure-Activity Relationship of Substituted Quinazolinones as Cyclin-Dependent Kinase 9 Inhibitors

Cyclin-dependent kinase 9 (CDK9) plays a critical role in transcriptional elongation, through which short-lived antiapoptotic proteins are overexpressed and make cancer cells resistant to apoptosis. Therefore, CDK9 inhibition depletes antiapoptotic proteins, which in turn leads to the reinstatement...

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Bibliographic Details
Main Authors: Hamad M. Alkahtani, Amer Alhaj Zen, Ahmad J. Obaidullah, Mohammed M. Alanazi, Abdulrahman A. Almehizia, Siddique Akber Ansari, Fadilah Sfouq Aleanizy, Fulwah Yahya Alqahtani, Rana M. Aldossari, Raghad Abdullah Algamdi, Lamees S. Al-Rasheed, Sami G. Abdel-Hamided, Alaa A.-M. Abdel-Aziz, Adel S. El-Azab
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
quinazolinones
cytotoxic agents
CDK9
molecular docking
Online Access:https://www.mdpi.com/1420-3049/28/1/120

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https://www.mdpi.com/1420-3049/28/1/120

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